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In a mouse model with I/R injury, the combination of cyclosporine A (CsA) and DFX synergistically inhibits I/R-induced iron overload, lipid peroxidation, and cardiomyocyte ferroptosis, reducing infarct size and improving poor cardiac remodeling after I/R injury
The depressive brain has been shown to exhibit a decrease in hippocampal neurogenesis, and this reduction is recovered by antidepressant drug treatment (Tanti and Belzung, 2013)
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